FORME À ENROBAGE MULTICOUCHE DE COMPOSITION PHARMACEUTIQUE À ADMINISTRATION PAR VOIE ORALE CONTENANT UN ACIDE GRAS OMÉGA-3 OU UN ESTER ALKYLIQUE DE CELUI-CI ET UN MÉDICAMENT À BASE DE STATINE
The present disclosure provides a pharmaceutical composition in multilayer-coated form including an omega-3 fatty acid or an alkyl ester thereof and a statin-based drug, and more particularly, a pharmaceutical composition for oral administration including: (a) a gelatin capsule core containing an omega-3 fatty acid or an alkyl ester thereof； (b) a first coating layer formed by coating, on the gelatin capsule core, hydroxypropyl methylcellulose and a copolymer of butyl methacrylate, (2-demethylaminoeethyl) methacrylate, and methyl methacrylate at a weight ratio of 1:2:1； and (c) a second coating layer formed by coating, on the first coating layer, a coating solution containing a statin-based drug.
