BRUCE, IAN,CHAMOIN, SYLVIE,COLLINGWOOD, STEPHEN PAUL,FURET, PASCAL,FURMINGER, VIKKI,LEWIS, SARAH,LOREN, JON CHRISTOPHER,MOLTENI, VALENTINA,SAUNDERS, ALEX MICHAEL,SHAW, DUNCAN,SVIRIDENKO, LILYA,THOMSON
申请号：
PE0008492014
公开号：
PE16742014A1
申请日:
2012.08.31
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to a compound of formula I, where a is m r1 is c1-4 alkyl, CN, among others, A1A is H, halogen, among others X is n or CH R2 is H, alkyl C1 - 8, among others R3 is H, cycloalkyl C3 - 10, between other R4 is h R5 is H, alkyl or haloalquilo c1-4 c1-4 alkyl R4 is C1, C8, haloalquilo C1 C8, among others.Preferred compounds are: N - (2-fluoro-5 - (2 - (4 - metilpiperazin - 1 - il) bencilcarbamoil) phenyl) - 7 - (1 - methyl - 5 - 1H pyrazole - il) imidazo [1,2-a] - 3 - pyridine carboxamide 7 - (3 - fluoro 4 - (2 - hidroxietilcarbamoil) phenyl) - N - (2 - 5 fluoro - (2 - (4 - metilpiperazin - 1 - il) bencilcarbamoil) phenyl) imidazole [1,2-a] - 3 - pyridine carboxamide Among others.This Compound is an inhibitor of the receptor, PDGF (platelet-derived growth factor). It also relates to a Pharmaceutical Composition and is useful in the treatment of pulmonary arterial hypertension.SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE: A ES M R1 ES ALQUILO C1-4, CN, ENTRE OTROS R1a ES H, HALOGENO,ENTRE OTROS X ES N O CH R2 ES H, ALQUILO C1-8, ENTRE OTROS R3 ES H, CICLOALQUILO C3-10, ENTRE OTROS R4 ES H R5 ES H, ALQUILO C1-4 O HALOALQUILO C1-4 R6 ES ALQUILO C1-C8, HALOALQUILO C1-C8, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-(2-FLUORO-5-(2-(4-METILPIPERAZIN-1-IL)BENCILCARBAMOIL)FENIL)-7-(1-METIL-1H-PIRAZOL-5-IL)IMIDAZO[1,2-A]PIRIDINA-3-CARBOXAMIDA 7-(3-FLUORO-4-(2-HIDROXIETILCARBAMOIL)FENIL)-N-(2-FLUORO-5(2-(4-METILPIPERAZIN-1-IL)BENCILCARBAMOIL)FENIL)IMIDAZOL[1,2-A]PIRIDINA-3-CARBOXAMIDA ENTRE OTROS. DICHO COMPUESTO ES UN INHIBIDOR DEL RECEPTOR PDGF (FACTOR DE CRECIMIENTO DERIVADO DE PLAQUETAS). TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y ES UTIL EN EL TRATAMIENTO DE LA HIPERTENSION ARTERIAL PULMONAR.
