Refers to compounds of cetoamida Dipeptidyl Derivatives of formula I, where C1 C8: R1 is alkyl, phenyl optionally substituted, among others R2 is alkyl C8 alkoxy optionally substituted C1, C1 to C8 alkyl - or - C1 C8, among others R3 is C1 C8 alkyl or benzyl optionally substituted The R4 is Chyle C1 C1 C8 C8, alkoxyl, among others X is a single link, or NH.Preferred compounds are: N - ((2S) - 1 - ((4 - (ethylamino) - 3,4 - [- 1 - 2 - fenilbutan - il) amino) - 4 - methyl - 1 - 2 - oxopentan - il) benzamide, N - ((2S) - 1 - ((4 - (ethylamino) - 4 - [1 - fenilbutan - il) - 2 - amino - 4 - methyl - 1 - 2 - oxopentan - il) Nicotinamide, among others.It also relates to compounds of formula II and IV, where X is o or NH A1A is C1 C8 alkyl, optionally substituted by alkoxyl (C1 - C6, C8, C10 alkyl (c1-c4), among others 2a is C1 C8 alkyl alkoxy optionally substituted with Fluorine, C1 C8 alkyl C1 C8 alkyl R3A, among Others is C1 - C8 or optionally substituted benzyl R4A is C1 - C3 alkyl C8, C6 alkyl - cicloalquil C0 C2,Among others. These compounds are useful in the treatment of Obesity and hyperlipidemiaSe refiere a compuestos derivados de dipeptidil-cetoamida de formula I, donde: R1 es alquilo C1-C8, fenilo opcionalmente sustituido, entre otros R2 es alquilo C1-C8 opcionalmente sustituido, alcoxi C1-C8-O-alquilo C1-C8, entre otros R3 es alquilo C1-C8 o bencilo opcionalmente sustituido R4 es alquilo C1-C8, alcoxilo C1-C8, entre otros X es un enlace sencillo, O u NH. Son compuestos preferidos: N-((2S)-1-((4-(etilamino)-3,4-dioxo-1-fenilbutan-2-il)amino)-4-metil-1-oxopentan-2-il)benzamida, N-((2S)-1-((4-(etilamino)-3,4-dioxo-1-fenilbutan-2-il)amino)-4-metil-1-oxopentan-2-il)nicotinamida, entre otros. Tambien se refiere a compuestos de formulas II y IV, donde X es O u NH R1a es alquilo C1-C8 opcionalmente sustituido con alcoxilo C1-C8, (arilo C6-C10)- alquilo C1-C4, entre otros R2a es alquilo C1-C8 opcionalmente sustituido con fluor, alcoxi C1-C8 - alquilo C1-C8, entre otros R
