DORONINA, SVETLANA O.,SENTER, PETER D.,TOKI, BRIAN E.,EBENS, ALLEN J.,KLINE, TONI BETH,POLAKIS, PAUL,SLIWKOWSKI, MARK X.,SPENCER, SUSAN D.
申请号：
ES04821486
公开号：
ES2456325T3
申请日:
2004.11.05
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound having the following formula: Formula ** ** or a pharmaceutically acceptable salt or solvate thereof wherein: regardless of each position: R2 is selected from H and C1-C8 alkyl R3 is selected from H, C1-C8 alkyl, C3-C8 carbocycle, aryl, alkaryl C1-C8, C1-C8 alkyl- (C3- C8 carbocycle), C3-C8 heterocycle and C1-C8 alkyl- (C3 heterocycle C8) R4 is selected from H, C1-C8 alkyl, C3-C8 carbocycle, aryl, alkaryl C1-C8, C1-C8 alkyl- (C3- C8 carbocycle), C3-C8 heterocycle and C1-C8 alkyl- (C3 heterocycle C8) R5 is selected from H and methyl or: R4 and R5 form together a carbocyclic ring and have the formula - (CRaRb) n- wherein Ra and Rb are independently selected from H, C1-C8 alkyl C3-C8 carbocycle and n is selected from 2 , 3, 4, 5 and 6 R6 is selected from H and C1-C8 alkyl R7 is selected from H, C1-C8 alkyl, C3-C8 carbocycle, aryl, alkaryl C1-C8, C1-C8 alkyl- (C3- C8 carbocycle), C3-C8 heterocycle and C1-C8 alkyl- (C3 heterocycle C8) each R8 is independently selected from H, OH, C1-C8 alkyl, C3-C8 carbocycle and O- (C1-C8) R9 is selected from H and C1-C8 alkyl R10 is selected from aryl and C3-C8 heterocycle Z is O and R11 is H.Un compuesto que tiene la siguiente fórmula:**Fórmula** o una sal o un solvato farmacéuticamente aceptables del mismo en el que: independientemente de cada posición: R2 se selecciona entre H y alquilo C1-C8 R3 se selecciona entre H, alquilo C1-C8, carbociclo C3-C8, arilo, alquil-arilo C1-C8, alquil C1-C8-(carbociclo C3- C8), heterociclo C3-C8 y alquil C1-C8-(heterociclo C3-C8) R4 se selecciona entre H, alquilo C1-C8, carbociclo C3-C8, arilo, alquil-arilo C1-C8, alquil C1-C8-(carbociclo C3- C8), heterociclo C3-C8 y alquil C1-C8-(heterociclo C3-C8) R5 se selecciona entre H y metilo o: R4 y R5 forman de manera conjunta un anillo carbocíclico y tienen la fórmula -(CRaRb)n-, en la que Ra y Rb se seleccionan independientemente entre H, alquilo C1-C8 y carbociclo C3-C8, y n se selecciona entre 2, 3, 4, 5 y 6 R6 se selecciona entre H y alquilo
