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Nuevos derivados de pirrolo[3,2-d]pirimidin-4-ona y su uso en terapia
专利权人:
ASTRAZENECA AB
发明人:
BOEGEVIG, ANDERS,LO-ALFREDSSON, YVONNE,PIVONKA, DONALD,TIDEN, ANNA-KARIN
申请号:
ES05812036
公开号:
ES2390888T3
申请日:
2005.12.05
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of formula (I) wherein: X represents S and Y represents O, L represents C1 to 7, incorporating said alkylene optionally a heteroatom seleccionadode S, S (O) n NR6, incorporating said alkylene optionally one or two carbon-carbon yestando said alkylene optionally substituted with one or more substituents seleccionadosindependientemente of OH, halogen, CN and NR4R5, C1 to 6 alkoxy and C1 to 6, optionally incorporating dichoalcoxi adjacent oxygen carbonyl n represents an integer 0, 1 or 2 R1 represents hydrogen, or i) a 3- to 7 saturated or partially unsaturated members optionally incorporating one heteroatom ears independently selected from O, N and S, and optionally incorporating agroup carbonyl, optionally substituted with one or more substituents seleccionadosindependientemente halogen, SO2R9, SO2NR9R10, OH, C1 to 7 alkyl, C1 to 7, CN, CONR2R3, NR2COR3 and COR3, and further stando said alkoxy optionally substituted by alkoxy C1a 6 and optionally incorporating said alkoxy adjacent oxygen carbonyl, and being ademásdicho alkyl optionally substituted by hydroxy or C1 to 6 and incorporating opcionalmentedicho alkyl or alkoxy adjacent oxygen carbonyl or any position in the alkyl oii) an aromatic ring selected from phenyl, biphenyl, naphthyl, or a structure monocyclic or bicyclic anilloheteroaromático containing 1 to 3 heteroatoms seleccionadosindependientemente of O, N and S, said aromatic ring system optionally sustituidocon one or more substituents selected independently halogen, SO2R9, SO2NR9R10, OH, C1 to 7 alkyl, C1 to 7, CN, CONR2R3, NR2COR3 and COR3 wherein said alcoxiopcionalmente further substituted by C1 to 6 and optionally incorporating said alkoxy adjacent oxygen uncarbonilo, and said alkyl being optionally further substituted by hydroxy oalcoxi C1 to 6 and optionally incorporating said alkyl or alkoxy carbonyl adjacent aloxígeno or in any position in the alkyl, R12 represents hydrogen or halogen or a carbon optionally substituted with one to three
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