BISSANTZ, CATERINA,GRUNDSCHOBER, CHRISTOPHE,MASCIADRI, RAFFAELLO,RATNI, HASANE,ROGERS-EVANS, MARK,SCHNIDER, PATRICK
申请号：
ES07847500
公开号：
ES2371784T3
申请日:
2007.11.29
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
The compound of the formula (I) in which X is C = O and Y is NR7, or X is CH2 and Y is O, or X is CH2 and Y is CH2； R1 is hydrogen, C1-6 alkyl, optionally substituted by CN or OH, or - (C1-6 alkylene) -C (O) -NRaRb； R2 is hydrogen, C1-6 alkyl, C1-6 alkoxy, - (C1-6 alkylene) -NRcRd, - (C1-6 alkylene) -C (O) Rf, benzyl, optionally substituted by one or more halogen, halo- C1-6 alkyl, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkoxy, nitro, or cyano, or phenyl, optionally substituted by one or more halogen, halo- C1-6 alkyl, C1-6 alkyl, C1 alkoxy -6, C1-6 haloalkoxy, nitro, or cyano； R3 is hydrogen, halogen, or C1-6 alkyl； R4 is hydrogen, halogen, C1-6 alkyl, halo- C1-6 alkyl, C1-6 alkoxy, halo- C1-6 alkoxy, or -O-C2-10 alkenyl； R5 is hydrogen, halogen, C1-6 alkyl, or C1-6 alkoxy； or R4 and R5 are joined with the benzo moiety to form a ring, in which -R4-R5- is -O- (CH2) n-O-, in which n is the number 1 or 2； R6 is hydrogen, C1-6 alkyl, optionally substituted by CN or OH, - (C1-6 alkylene) -NRgRh, - (C1-6 alkylene) -C (O) -NRiRj, -O-benzyl, optionally substituted by one or more halogen, halo- C1-6 alkyl, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkoxy, nitro, or cyano, nitro, halogen, cyano, C1-6 alkoxy, halo C1-6 alkoxy, halo -C1-6 alkyl, - (C1-6 alkylene) -C (O) Rf, phenyl, or a 5 or 6-link heteroaryl, optionally substituted by halogen, halo- C1-6 alkyl, C1-6 alkyl, C1 alkoxy -6, C1-6 haloalkoxy, nitro, or cyano, - (C1-3 alkylene) -Rm, wherein Rm is phenyl, a 5- or 6-link heteroaryl, a 4-6 link heterocycloalkyl or a cycloalkyl from 3 to 6 links, each of them is optionally substituted by one or more halogen, halo-C 1-6 alkyl, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 halo-alkoxy, nitro, or cyano； or R5 and R6 are joined with the benzo moiety to form a ring, in which -R5-R6- is: -O- (CH2) nC (O) -, -C (O) - (CH2) nO-, or -O- (CH2) nO-, in which n is the number 1 or 2； R7 is hydrogen or C1-6 alkyl； R8 is hydrogen, C1-6 alkoxy, CN, OH, COORn, or C (O) NRoRp； R9, R10 and R11 independently of one
