БРЮСТЕР Уилльям (US),КЛИТТИЧ Карла (US),РИДЕР Брент (US),СИДДАЛЛ Томас (US),ЯО Чэнлинь (US)
申请号：
RU2012133570/13
公开号：
RU2012133570A
申请日:
2011.01.06
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A compound of formula (IA) :, wherein: R is H, lower alkyl, phenyl, pyridine N-oxide, or a heterocycle comprising a 5- or 6-membered single ring, wherein lower alkyl, phenyl, pyridine N-oxide or a 5- or 6-membered single-ring heterocycle, optionally substituted by halogen, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO, CN, lower alkoxycarbonyl, lower alkanoyl, lower alkyl-SO, and aldoximes and lower alkiloksimy optionally substituted on the oxygen with lower alkyl Z Representing H, C-C single bond, CH, NH, O, S, CHO, OCH, CHCHO, or OCHCH represents 4, represents 0 or 1 q is an integer from 0 to 2 R is independently H, halogen, lower alkyl, lower alkenyl, lower alkynyl, hydroxy, lower alkoxy, haloalkyl, haloalkoxy, NO, CN, lower alkanoyl, lower alkoxycarbonyl, mercapto, lower alkylthio, aldoximes and lower alkiloksimy optionally substituted on the oxygen with lower alkyl Y represents CC single bond, C (R) O or C (R) represents 2 R is independently H or lower alkyl R is H, halogen, lower alkyl, lower alkoxy, or lower haloalkyl R is independently H or lower alkyl and X represents NR, O and S, where R c is selected from H, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, hydroxy, lower alkoxy, lower alkyl-SO, phenyl-substituted phenyl SOili-SO.2. A compound according to claim 1, wherein R3 and R4 are H and X is NR3.3. A compound according to claim 2, wherein Y represents C (R5) .4. A compound according to claim 3, wherein R1 represents H, lower alkyl, lower alkoxy, or g1. Соединение формулы (I-A):,в которой:R представляет собой Н, низший алкил, фенил, пиридин N-оксид, или гетероцикл, включающий 5- или 6-членное одиночное кольцо, где низший алкил, фенил, пиридин N-оксид, или 5- или 6-членный одиночно-кольцевой гетероцикл необязательно замещены галогеном, низшим алкилом, низшим алкокси, бензилокси, низшим алкенилом, низшим алкинилом, галогеналкилом, галогеналкокси, NO2, CN, низшим алкоксикарбонилом, низшим алканоилом, н
