Claim 1: a compound of the formula (1) or a n-oxide thereof, or a pharmaceutically acceptable Salt of the compound or the n-oxide, where each r¹, when present,Regardless of the selected Group is Halogen, hydroxy -, cyano, Nitro, c₁₋₆ sf₅, optionally substituted alkyl, optionally substituted alquenilo c₂₋₆,Alquinilo c₂₋₆ optionally replaced, Alquiltio c₁₋₆ alkoxy optionally substituted cycloalkyl, optionally substituted c₁₋₆, c₃₋₆ optionally replaced,C₃₋₆ optionally substituted cycloalkyl - or -, - N (r³) (r⁴), N (r³) - C (= o) (r⁴) - C (= o) n (r³) (r⁴) - or - C (= o) - N (r³) (r⁴) - C r³ (= O) -, - C (= o) - or³ selected a is an integer of 0, 1, 2, and 3 each R²,When it occurs, is selected from the group consisting of independently sf₅ - hydroxy alkyl, Nitro, c₁₋₆ optionally replaced, alquenilo c₂₋₆ optionally replaced,Alquinilo c₂₋₆ optionally replaced, Alquiltio c₁₋₆ alkoxy optionally substituted, optionally substituted N - (c₁₋₆, r³) (r⁴), N (r³) - C (= o) (r⁴) - C (= o) n (r³) (r⁴) - or - C (= o) - N (r³ (r⁴) - C (= o) - r³,And - C (o) - or³ selected b is an integer of 0, 1, 2, 3, and 4 are selected L - (ch₂) ₘ -, - O -, - NH -,Where M is an integer of 1 and 2 selected is absent or is selected from the group consisting of c₃₋₆ cycloalkyl and heterocicloalquilo (4 - 10 members)Where the heterocicloalquilo cycloalkyl and optionally replace each with one to five substituents selected from the group consisting of independently Halogen, Hydroxy, cyano,- sf₅ optionally substituted alkyl, Nitro, c₁₋₆, alquenilo c₂₋₆ optionally replaced, alquinilo c₂₋₆ optionally replaced, Alquiltio c₁₋₆ optionally replaced,C₁₋₆ alkoxy optionally substituted N - (r³) (r⁴), N (r³) - C (= o) (r⁴) - C (= o) n (r³) (r⁴) - or - C (= o) - N (r³ (r⁴) - C (= o), r³) -, - C (= o) - or³ cycloalkyl c₃₋₁₂ is selected and,Aryl and heteroaryl c₆₋₁₀ (5 to 10 members), where cycloalkyl, aryl,Heteroaryl substituted and optionally with one to five substituents selected from the group consisting of indep
