КОЛКА Джерард Р. (US),ГЭДВУД Роберт К. (US),ПАРКЕР Тимоти (US)
申请号：
RU2012149458/04
公开号：
RU2012149458A
申请日:
2011.04.20
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method of treating non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH), comprising administering to a patient a pharmaceutical composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, in which: each of R and R is independently selected from H, halogen, aliphatic radical and alkoxy, wherein the aliphatic radical and alkoxy may be substituted by 1 to 3 halogen atoms； R is halogen, hydroxy, or optionally substituted aliphatic radical, and is H, or R together form an ox ； Roboznachaet H； and A is phenyl. 2. The method of claim 1, wherein R is H.3. A process according to any one of claims 1 or 2, wherein R is H, methyl, methoxy, ethoxy, —O — isopropyl, —OCHF, or —OCF. 4. The method of claim 3, wherein R is H.5. The method according to claim 3, wherein R is H, halogen or optionally substituted alkoxy. The method of claim 3, wherein R is H.7. The method of claim 3, wherein R is halogen. The method according to claim 7, wherein R is in the para- or meta-position of the phenyl ring. The method of claim 7, wherein R is in the meta position of the phenyl ring. The method of claim 8, wherein R is F or Cl. 11. The method of claim 5, wherein R is optionally substituted alkoxy. The method of claim 11, wherein R is in the meta or ortho position of the phenyl ring. The method of claim 11, wherein R is in the meta position of the phenyl ring. The method of claim 12, wherein R is methoxy, ethoxy or —O-isopropyl. The method of claim 12, wherein R is —OCHF or —OCF. 16. The method of claim 1, wherein H.17. The method of claim 16, wherein R is hydroxy. The method according to claim 1, in which R together form an oxo. The method according to claim 1, in which the compound of the formulas1. Способ лечения неалкогольного жирового заболевания печени (NAFLD) или неалкогольного стеатогепатита (NASH), включающий введение пациенту фармацевтической композиции, включающей соединение формулы I:или его фармацевтически приемлемую
