КОУ Джотам Уодсуорт (US),АЛЛЕН Джон Артур (US),ДЭЙВОРЕН Дженнифер Элизабет (US),ДОУНЭЙ Эми Бет (US),ЕФРЕМОВ Иван Викторович (US),ГРЭЙ Дэвид Лоуренс Фирман (US),ГИЛМЕТТ Эдвард Рэймонд (US)
申请号：
RU2015115400
公开号：
RU2015115400A
申请日:
2013.10.29
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A compound of formula I or an N-oxide thereof or a pharmaceutically acceptable salt of said compound or said N-oxide wherein X is O or S； Y is O, S or NR； Q is N-containing 5-10 membered heterocycloalkyl, N-containing 5-10 membered heteroaryl or phenyl, wherein heterocycloalkyl or heteroaryl is optionally substituted with 1, 2, 3, 4, or 5 independently selected R； and phenyl is optionally substituted with 1, 2, 3, 4, or 5 independently selected R； each of R and R is independently selected from the group consisting of H, C1-6alkyl, Cfluoroalkyl, cyclopropyl, fluorocyclopropyl, Salkoxy, Haloalkoxy, groups —C (= O) —O - (C1-6alkyl) and -C (= O) OH； R is selected from the group consisting of H, F, groups -C (= O) OH, -C (= O) -O- (C1-6alkyl), C1-6alkyl, Cfluoroalkyl, Cycloalkyl and fluorocycloalkyl, wherein said cycloalkyl is optionally substituted with 1, 2, 3, 4 or 5 substituents, each independently selected from halogen, C1-6alkyl, haloalkyl, alkoxy, and haloalkoxy； R is selected from the group consisting of H , halogen, —CN, —OH groups, C (= O) OH, C (= O) —O- (C1-6alkyl), Calkoxy, Calogenoalkoxy, —N (R) (R), C 1-6 alkyl, Cfluoroalkyl, Cycloalkyl, Cfluorocycloalkyl, Salkenyl and C1-6alkynyl, wherein said C-cycloalkyl is optionally substituted with 1, 2, 3, 4 or 5 substituents, each independently selected from halogen, C1-6alkyl, Halogenated, Salkoxy and halogenoalkoxy； each of R and R is independently selected from the group consisting of H, C 1-6 alkyl, C 1 haloalkyl, C 1 alkoxy, C 1 haloalkoxy, —CN, Cycloalkyl, —C (═O) OH, C (═O) —O— (C 1-6 alkyl) and halogen, where each of the above C 1-6 alkyl and Cycloalkyl is possible substituted with 1, 2, 3, 4 or 5 substituents, each independently selected from halogen, —OH, —CN, C 1-6alkyl, Haloalkyl, Salkoxy and Haloalkoxy； each of R and R is independently selected from the group consisting of H, halogen, —OH , -NO, -CN, C1-6alkyl, Haloalkyl, Haloalkoxy, Salkenyl,1. Соединение формулы Iили его N-оксид или фармацевтическ
