THE JOHNS HOPKINS UNIVERSITY;ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
发明人:
BARBARA SLUSHER,DAVID VOLSKY,MIKE NEDELCOVYCH,KRISTEN HOLLINGER,ATSUSHI KAMIYA
申请号：
US15884974
公开号：
US20180193362A1
申请日:
2018.01.31
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The disclosure provides compounds having formula (I):and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, and X are as defined as set forth in the specification, for use in treating cognitive deficits and/or psychiatric disorders, such as those associated with neurological or neurodegenerative disorders, psychiatric or mood disorders, and HIV-associated neurocognitive disorders (HAND). Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON).
