Institute of Organic Chemistry and Biochemistry AS CR, V.V.I.;THE JOHNS HOPKINS UNIVERSITY
发明人:
SLUSHER, Barbara,RAIS, Rana,TENORA, Lukas,MAJER, Pavel,JANCARIK, Andrej
申请号：
HK18115348
公开号：
HK1256284A1
申请日:
2018.11.30
申请国别(地区):
HK
年份:
2019
代理人:
摘要：
and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.
