Ústav organické chemie a biochemie AV CR, v.v.i.;THE JOHNS HOPKINS UNIVERSITY
发明人:
Barbara Slusher,Rana Rais,Lukas Tenora,Pavel Majer,Andrej Jancarik
申请号：
US16454880
公开号：
US20190315784A1
申请日:
2019.06.27
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The disclosure provides compounds having formula (I):and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′；, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.
