The Johns Hopkins University;Institute of Organic Chemistry and Biochemistry AS CR, V.V.I.
发明人:
申请号：
EP16833623.8
公开号：
EP3328827A4
申请日:
2016.07.29
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.
