LEE, HYUN JUN,이현준,KIM, JONG HOON,김종훈,KIM, YOON A,김윤아,PARK, SOO HYUN,박수현,JUNG, SUNG UG,정성욱,MIN, BYUNG JUNG,민병중,LEE, HYUN JUNKR,KIM, JONG HOONKR,KIM, YOON AKR,PARK, SOO HYUNKR,JUNG, SUNG UGKR,MIN, BYUNG JUNGKR
申请号：
KR1020140168383
公开号：
KR1020160065280A
申请日:
2014.11.28
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a killed lactobacillus having an immunity regulating function and a method for producing the same. In particular, effects have been exhibited by regulating the activity of a biomarker related to immunity regulation by means of killed bacteria of Lactobacillus brevis NS1401 (donated by Korean Federation of Culture Collections affiliated with Korean Culture Center of Microorganisms, donation number: KCCM11594P, donation date: 30.10.2014) separated from kimchi. Specifically, Lactobacillus brevis NS1401 developed according to the present invention has an excellent immunity regulating effect thereof compared to other strains separated from kimchi, and has high acid resistance and bile acid resistance, so the Lactobacillus brevis NS1401 may also be excellently used as probiotics. The present invention relates to the strain properties of Lactobacillus brevis NS1401 separated from kimchi, an excellent immunity regulating effect thereof when being killed, and a method for producing the same so as to improve effects thereof. Moreover, killed bacteria developed according to the present invention may be variously used in producing a chemical composition, a drinkable intestinal agent, a probiotic composition, a feed additive, and other fermentation products. The method comprises the steps of: sorting a strain having excellent acid resistance and bile acid resistance from kimchi, and heating and killing the strain； and analyzing the strain properties of sorted Lactobacillus brevis NS1401, and improving an immune regulating effect of killed bacteria thereof.본 발명은 면역조절 기능이 강화된 유산균 사균체 및 이의 제조방법에 관한 것이다. 특히 김치로부터 분리된 락토바실러스 브레비스 NS1401(Lactobacillus brevis, 기탁기관: 한국종균협회부설 한국미생물보존센터, 수탁번호: KCCM11594P, 수탁일자: 2014.10.30.) 유산균의 사균체로, 면역조절 관련 바이오마커의 활성을 조절함으로써 효능을 나타내었다. 특히 본 발명을 통해 개발된 락토바실러스 브레비스 NS1401(Lactobacillus brevis)는 김치로부터 분리되는 타 균주에 비해 그 면역조절 효능이 우수하며, 내산성/내담즙산성이 높아 프로바이오틱스로서도 우수하다. 본 발명은 김치로부터 분리된 락토바실러스 브레비스 NS1401(Lactobacillus brevis)의 균
