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Diazepinone derivatives useful for the treatment of fragile X syndrome, Parkinson's disease or reflux
专利权人:
Novartis AG
发明人:
BEHNKE, Dirk,CARCACHE, David,ERTL, Peter,KOLLER, Manuel,ORAIN, David
申请号:
ES13783671
公开号:
ES2672737T3
申请日:
2013.08.21
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of the formula I ** Formula ** or a salt thereof, wherein A is a fused monocyclic ring system of five to seven members that may be aromatic, saturated or unsaturated non-aromatic and may contain 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur; R1 is halogen; cyano; nitro; hydroxy; Not me; -C (O) H; -C (O) NH2; -X1-R5; or -X2-B2; X1 is selected from link; carbonyl; oxygen; sulfur; -SW)-; -S (O) 2-; amino, which may be substituted with C1-4 alkyl; -NH-C (O) -; -C (O) -NH-; -C (O) -O-; -O-C (O) -; -NH-S (O) 2-; -S (O) 2-NH-; and -NHC (O) NH-; R5 is C1-6 alkyl; C1-6 halogenoalkyl; C1-6 cyanoalkyl; C1-6 carboxyalkyl; C1-6 hydroxyalkyl; C1-4 alkoxy-C1-6 alkyl; C1-4 alkoxy-C1-4 alkoxy-C1-6 alkyl; C 1-4 alkylcarbonylC 1-6 alkyl; C1-4 alkoxycarbonyl-C1-6 alkyl; C 1-4 alkylcarbonyloxyC 1-6 alkyl; C1-6 aminoalkyl; C1-4 alkylamino-C1-6 alkyl; di (C 1-4 alkyl) aminoC 1-6 alkyl; C 1-6 aminocarbonylalkyl; C1-4 alkylaminocarbonyl-C1-6 alkyl; di (C1-4 alkyl) aminocarbonyl-C1-6 alkyl; C1-4 alkyl C1-6 carbonylaminoalkyl; C 1-4 alkylaminosulfonyl-C 1-6 alkyl; di (C1-4 alkyl) aminosulfonyl- C1-6 alkyl; C2-6 alkenyl; C2-6 halogenoalkenyl; C2-6 alkynyl; C2-6 halogenoalkynyl; X2 is a C1-3 alkylene bond or bond, wherein a C1-3 alkylene carbon atom can be replaced by a selected group of carbonyl; oxygen; sulfur; -SW)-; -S (O) 2-; amino, which may be substituted with C1-4 alkyl; -NHC (O) -; -C (O) -NH-; -C (O) -O-; -O-C (O) -; -NH-S (O) 2-; -S (O) 2-NH-; and -NHC (O) NH-; B2 is a three to seven membered monocyclic ring system that can be aromatic, saturated or unsaturated non-aromatic and can contain 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, in which the ring system can in turn be replaced once or more than once by R6; each R6 is independently halogen, hydroxy, cyano, C1-4 alkyl, C1-4 halogenoalkyl, C1-4 alkoxy or C1-4 halogenoalkoxy; or two R6 in the same ring atom are both oxo; m is 0, 1, 2, 3 or 4; each R2 is independently halogen, cyano, hydroxy
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