БРЭЙ Эрик (US),ДРАПАЛА Павел (US),ХИЦ Ханс (CH),ЦЗЯН Бинь (US),КАН-МАЙЛЕР Дженнифер (US),ПЕРЕС-ЛУНА Виктор (US),ШЕФЕР Рольф (CH)
申请号：
RU2013143401/15
公开号：
RU2013143401A
申请日:
2012.03.05
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A composition comprising a thermosensitive hydrogel and a biocompatible monomer or polymer comprising an amino acid linked via a side chain, characterized in that the hydrogel is thermosensitive at physiological temperature. The composition of claim 1, further comprising a drug composition, a biomolecule and / or a nanoparticle. A composition according to claim 1 or 2, characterized in that the biocompatible monomer or polymer contains an amino acid linked via its side chain to an acrylic, maleic or phthalic derivative. The composition according to claim 1, wherein the amino acid is lysine, tyrosine, series, cysteine, proline, or combinations or derivatives thereof. The composition according to claim 1, characterized in that the thermosensitive hydrogel contains a hydrophilic polymer that reacts with a crosslinking agent. The composition of claim 5, wherein the crosslinking agent comprises polyethylene glycol diacrylate, bisacrylamide or functionalized dithiol molecules. A composition according to claim 1, characterized in that the thermosensitive hydrogel contains N-isopropyl acrylamide, and the biocompatible monomer or polymer contains lysine, tyrosine, serine, cysteine, proline, or combinations or derivatives thereof. A composition according to claim 7, characterized in that N-isopropyl acrylamide is crosslinked with polyethylene glycol diacrylate, bisacrylamide or functionalized dithiol molecules. The composition of claim 1, further comprising N-tert-butyl acrylamide (NtBAAm). The composition according to claim 1, characterized in that the composition is a means for treating wounds. The composition of claim 10, further comprising an antimicrobial agent. Component1. Композиция, содержащая термочувствительный гидрогель и биосовместимый мономер или полимер, включающий аминокислоту, связанную посредством боковой цепи, отличающаяся тем, что гидрогель является термочувствительным при физиологической температуре.2. Композиция по п.1, дополнительно содержащая лекарст
