您的位置: 首页 > 农业专利 > 详情页

AGONISTAS DUALES DE GLP1/GIP O TRIGONALES DE GLP1/GIP/GLUCAGON
专利权人:
SANOFI
发明人:
申请号:
ARP130104914
公开号:
AR094181A1
申请日:
2013.12.19
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
Claim 1: Peptide Compound with the formula (1): r\u00b9 R\u00b2 - Z - (1) where z is a Peptide which has the formula (2): X - AIB - Tyr THR Gly Phe - Thr ser ASP Leu - - - - - - x\u00b9\u2074 x\u00b9\u00b2 Gin x\u00b9\u2075 x\u00b9\u2076 x\u00b9\u2077 x\u00b9\u2078 - - - - - - - x\u00b9\u2079 x\u00b2\u2070 x\u00b2\u00b9 PHE ile Glu Lys TRP - Leu - x\u00b2\u2078 - x\u00b2\u2079 Gly pro - R be giy ala pro ser pro Pro - x\u2074\u2070 (2) X represents an amino acid selected from GLNGlu and his Rest x\u00b9\u00b2 represents an amino acid selected from Lys ile and rest x\u00b9\u2074 represents an amino acid with a side chain that has a group of - nh\u2082, where the side chain - Group nh\u2082 is functionalized with - C (o) - r\u2075, where r\u2075 can be a rest... Thus up to 50 or even 100 carbon Atoms and optionally hetero Atoms selected from Halogen, N, or,S and \/ or P x\u00b9\u2075 represents a rest of selected amino acid between ASP and Glu x\u00b9\u2076 represents an amino acid selected from rest of Lys, glu, GLN and rest x\u00b9\u2077 represents an amino acid selected from Arg, Lys, glu, GLN, LEU, Tyr ala AIB, and x\u00b9\u2078 Amin represents a rest O\u00e1cido selected among ala, ARG, LEU and Tyr AIB x\u00b9\u2079 represents an amino acid selected from other WingVal and AIB rest of x\u00b2\u2070 represents an amino acid selected from GLN, LEU, PHE, AIB, Lys, his, PIP (S) melys, melys (R) and (S) meorn x\u00b2\u00b9 represents an amino acid selected from rest of ASP, glu and leu x\u00b2\u2078 represents an amino acid selected from other ASN ala AIB and X \u2079 represents an amino acid selected from rest of THR, Gly, AIBD - ala and ala Lys x\u2074\u2070 is absent or represented r\u00b9 represents nh\u2082 R\u00b2 group represents the c-terminal Peptide compound and select between Oh and nh\u2082 or a Salt or solvate thereof.Claim 23: The Compound for use according to claim 18 to 22 for the Treatment or prevention of hypoglycemia, Type 2 diabetes, Obesity and meta
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充