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Human antibodues against hepatitis C virus (HCV) E2 protein and uses thereof
专利权人:
UNIVERSITY OF MASSACHUSETTS
发明人:
BROERING, TERESA,SLOAN, SUSAN,BABCOCK, GREGORY, J,AMBROSINO, DONNA,THOMAS, WILLIAM, D
申请号:
NZ57970608
公开号:
NZ579706A
申请日:
2008.02.13
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
A human antibody that binds to a non-conformational (linear) epitope of the E2 protein of hepatitis C virus (HCV) that comprises: (a) A heavy chain CDR3, CDR2, CDR1 comprising SEQ ID NOs: 9, 8 and 7 respectively and a light chain CDR3, CDR2 and CDR1 comprising SEQ ID NOs: 18, 17 and 16 respectively; (b) A heavy chain CDR3, CDR2, CDR1 comprising SEQ ID NOs: 12, 11 and 10 respectively and a light chain CDR3, CDR2 and CDR1 comprising SEQ ID NOs: 21, 20 and 19 respectively; or (c) A heavy chain CDR3, CDR2, CDR1 comprising SEQ ID NOs: 15, 14 and 13 respectively and a light chain CDR3, CDR2 and CDR1 comprising SEQ ID NOs: 24, 23 and 22 respectively.
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