ГАРНИ Остин Л. (US),САТО Аарон Кен (US),АКСЕЛЬРОД Фумико Такада (US),ХОЕЙ Тимоти Чарльз (US),САТЬЯЛ Санджив Х. (US),МИТРА Сатьяджит Суджит Кумар (US)
申请号：
RU2011110405/15
公开号：
RU2011110405A
申请日:
2009.09.28
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. An agent that specifically binds to a frizzled human receptor selected from the group consisting of FZD1, FZD2, FZD5, FZD7 and FZD8, wherein said agent:! (a) binds at least part of the sequence Q (DE / ED) AGLEVHQF (Y / W) PL (SEQ ID NO: 24) as part of the human frizzled receptor, and / or! (b) binds to at least part of the sequence (K / Q) (F / Y) GF (Q / A) (SEQ ID NO: 69) in the human frizzled receptor. ! 2. An agent that competes for specific binding to the FZD1, FZD2, FZDS, FZD7 and / or FZD8 receptors with a human antibody in a competitive binding assay, wherein said antibody contains a heavy chain variable region comprising SEQ ID NO: 10 and a variable region light chain comprising SEQ ID NO: 12 or SEQ ID NO: 14.! 3. An agent that competes for specific binding to FZD5 and / or FZD8 receptors with an antibody in a competitive binding assay, said antibody comprising a heavy chain variable region comprising SEQ ID NO: 85 and a light chain variable region comprising SEQ ID NO : 86.! 4. An agent that specifically binds to FZD8, with the specified agent:! (a) binds at least part of the sequence GLEVHQ (SEQ ID NO: 25) in the composition of FZD8； and / or! (b) binds to at least part of the QYGFA sequence (SEQ ID NO: 66) in the composition of FZD8. ! 5. The agent according to claim 4, which additionally specifically binds to FZD1, FZD2, FZD5, and / or FZD7 person. ! 6. An antibody that specifically binds to the FZD1, FZD2, FZD5, FZD7 and FZD8 receptors. ! 7. An agent that specifically binds to the human frizzled receptor, wherein said agent binds to at least a portion of the biological binding site (BSS) of the human frizzled receptor. ! 8. The agent according to claim 7, characterized in that the receptor1. Агент, специфично связывающийся с рецептором frizzled человека, выбранным из группы, включающей FZD1, FZD2, FZD5, FZD7 и FZD8, при этом указанный агент: ! (а) связывается, по меньшей мере, с частью последовательности Q(DE/ED)AGLEVHQF(Y/W)PL (SEQ ID NO: 24) в с
