The invention provides compounds of the formula:R 1 is OR11, or NR5R5 R2 is H or F R5 is H, C1-C6alkyl, OH, C(=O)R6, O(C=O)R6 or O(C=O)OR6 R5 is H or C1-C6alkyl R6 is C1-C6alkyl or C3-C7cycloalkyl R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22 and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.本發明提供下式之化合物,R 1 為OR11、或NR5R5;R2為H或F;R5為H、C1-C6烷基、OH、C(=O)R6、OC(=O)R6或OC(=O)OR6;R5為H或C1-C6烷基;R6為C1-C6烷基或C3-C7環烷基;R13為H、苯基、吡啶基、苄基、吲哚基或萘基,其中該苯基、吡啶基、苄基、吲哚基及萘基視情況經1、2或3個R22取代;且其他變數如申請專利範圍中所定義,其係用於治療癌症,及相關態樣。
