COMBINATIONS CONTAINING PDE 2 INHIBITORS, SUCH AS 1-ARIL-4-METHYL- [1,2,4] TRIAZOLO [4,3-A] CHINOXALINE COMPOUNDS, AND PDE 10 INHIBITORS FOR USE IN TREATMENT OF SMALL PROMISES
1. A product containing as a first active ingredient a PDE2 inhibitor, in particular a compound of formula (I): or a stereochemically isomeric form thereof, wherein R is phenyl or pyridinyl, each of which is optionally substituted with 1 or 2 substituents independently selected from the group consisting of halogen, (Cycloalkyl) C1-6alkyloxy and C1-6alkyloxy； and R is —CH — NRR； wherein R is hydrogen or methyl； R is C1-6alkyl； or NRR is morpholinyl； or a pharmaceutically acceptable salt or solvate thereof； and as the second active ingredient, one or more PDE10 inhibitors in the form of a combined preparation for the simultaneous, separate or sequential use in the treatment of patients suffering from neurological or mental disorders or endocrine or metabolic diseases. 2. The product according to claim 1, characterized in that one or more PDE10 inhibitors are selected from MP-10； PQ-10； TR-10； papaverine； the compounds of formula (II): or a stereoisomeric form thereof, wherein R ′ is pyridinyl； pyridinyl optionally substituted with halogen, C1-6alkyl, trifluoromethyl or C1-6 alkyloxy； tetrahydropyranyl or NR′R ′； R ′ represents hydrogen, C1-6alkyl, trifluoromethyl, Cycloalkyl or Salkyloxy； R ′ represents hydrogen, chlorine, C1-6alkyl, trifluoromethyl or Cycloalkyl； Het ′ represents a 5- or 6-membered heterocyclic ring selected from the group consisting of pyridinyl, pyrimidinyl, pyridazinyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isothiazolyl, isoxazolyl, oxadiazolyl and triazolyl； R ′ is hydrogen, C1-6alkyl, trifluoromethylSalkyl, hydroxycyclopropyl,1. Продукт, содержащий в качестве первого активного ингредиента ингибитор PDE2, в частности соединение формулы (I):или его стереохимически изомерную форму,гдеRпредставляет собой фенил или пиридинил, каждый из которых необязательно замещен 1 или 2 заместителями, независимо выбранными из группы, состоящей из галогена, (Сциклоалкил) Cалкилокси и Салкилокси； иRпредставляет собой -CH-NRR；гдеRпредставляет собой во
