A composition with anoxia-tolerant and anti-fatigue functions, which is prepared by the following active ingredients: Arillus Longan, Fructus Jujubae, Radix Rehmanniae Preparata, Fructus Lycii, Semen Juglandis, Fructus Schisandrae Chinensis, Cortex Cinnamomi, and Cornu Cervi Pantotrichum. The invention further provides a use of aforesaid composition in the preparation of the health food with anoxia-tolerant and anti-fatigue functions. The health food of the present invention is prepared with natural Chinese herbal medicine as the major raw materials, can be administered for a long time, the result of functional experiment prove that, the health food of the present invention has anoxia-tolerant and anti-fatigue functions, the effect is significant.
