TURNER JR., WILLIAM W.,LI, LEPING,HAYDAR, SIMON N.,BURES, MARK G.,RAI, ROOPA,FRANCIS, SAMSON,ARNOLD, LEE D.
申请号：
ARP180100493
公开号：
AR111225A1
申请日:
2018.03.02
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
CyclosulfonamidesDrug ingredients including themThey are the core protein modulators of hepatitis B virus (HBV). It is used in the treatment of hepatitis B (HBV) infection. Claim 1: A formula compound (1),Or salt with acceptable efficacyW is 2；R1 is phenyl or pyridine.Each of them is optional.Two or three alternatives selected independently from the halo group.- Oh,- um.- No. 8322；Oxo,HydrazineKrabi,Azido,SiliconSiloxi,- S(o) Q-C8321833183268； Tenant；- No. 7491； No. 74955；- 758080-S(O)8348； -C832183318326； asphalt；- S(O) 8348； - No. 7491； R74955；C8321833183263； Rent,C8322283318326263； Alquenilo,C8322283318326263； tar；C8332383318326263； cycloquilo,Halo-C8321883318326263； -Acquilo,1. Hidroxi-C832183-318326； "Acquilo,R7491； R74955； N-C832183318326； Asphalt-,C8321833183263； Alcoxi,Halo-C8321883318326； Alcoxi,1. Hidroxi-C83218C83331-8326； Alcoxi-,R7491； R74955； N-C832183318326； Alcoxi-,C8321C8331836283； - alcoxi - C832183316283； - asphalt；- C(O) No. 7491； (R7495)；- c(o) - C832138.8326； Rent. - C (o) oh y-c (o) o-C83316283；R2 is hydrogen；R3 is selected from the group consisting of the residues of the formula group (2).Among them: R830808 is hydrogen or C832131； 832626； asphalt can be replaced by an alternative.Two or three substitutes were independently selected from the halogen group.- Oh,- um.- S(o) Q-C8321833183268； Tenant；- No. 7491； No. 74955；- 758080-S(O)8348； -C832183318326； asphalt；- S(O) 8348； - No. 7491； R74955；C8322283318326263； Alquenilo,C8322283318326263； tar；Halo-C8321883318326263； -Acquilo,C8321833183263； Alcoxi,Halo-C8321883318326； Alcoxi,- C(O) No. 7491； (R7495)；- c(o) - C832138.8326； - Tenant；Krabi,- C(o) Oh,- C(O) O-C 8321833183268； - lessor,phenylC832183318324； - alcoxiphenyl,PyrethrinMofflin.4. Tetrahydrofuran and cyanide；R83099 is hydrogen or C83218331832626； alternative tars are selected from the halogen group.- Oh,C8321833183263； Alcoxi,- No. 7491； No. 74955；E. R7491 and R7495； n-C8321833183248 lessors；R83100s is hydrogen or C8321833183263； tar；R3
