PILUSHCHEV, MARINA A.,SIDRAUSKI, CARMELA,MARTIN, KATHLEEN ANN,DART, MICHAEL J.,CHUNG, SEUNGWON,TONG, YUNSONG,ZHANG, QINGWEI I.,SHI, LEI,SWEIS, RAMZI FARAH,XU, XIANGDONG,BLACK, LAWRENCE A.,FROST, JENNI
申请号：
ARP180103194
公开号：
AR113825A1
申请日:
2018.11.02
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
This report provides useful compounds, compositions and methods for the regulation of integrated stress response (ISR) and the treatment of related diseases, disorders and diseases. 1. Property 1: a formula compound (1) or its salts, solutions, hydrates, tormentometers, esters, positive oxides or stereoisomers, wherein D is a bicyclic bridge, a bicyclic bridge, a Unicyclic bicycle bridge or a Cuban bicycle bridge 2. 1-4 RX groups can be used to replace double ring isomerization bridge, double ring bridge or Cuba bridge；If the bicycles on the bridge contain residual replaceable nitrogen, RN can be used to replace the remaining replaceable nitrogen；No. 1 and No. 2 are c8332121 and c831832626 respectively.Alquenileno C8322328331-832626；2-7 members or heterosexual NRC, each c8321833183226；a. Heterosexual members of alquenileno c83228331832626 or 2-7 could be replaced by 1-5 RL； R1 and R2 were hydrogen, c8332183331 and c832626 tar, respectively；Alcoxi C83218C83331°-832626-Acquilo C83222318326；1.Hidroxi-Acquilo C832232833126；1. Silicate-c833223531832626；G1-o-lessor c8332228331832626；a. Ho ° 8322； - c-asphalt c8332131；Each RL is independently selected from rental unit c83321218331832626；1.hydroxi-codilo C83217C8331832626；Hidroxi-alcoxi C83217C83316262；a.Halo-Acquilo C83217C8331832626；1.Amino-Acquilo C83217C8331832626；Ciano-Acquilo C83217C8331832626；Alcoxi C83218C83331°-832627-Acquilo C8321883316262；Ho. 83222； - c-asphalt c8332131；1. C83218c8331c8326c (o) 832222-c-asphalt c83321c83316c；Oxo, halo, Ciano, ora, nrbrc, nrbrcc, NBC (o) rd, C (o) nrbrc, C (o) Wu, C (o) ord, SRE, s (o) rd, s (o) rd, s (o) 83222； RD, OS (o) rd, OS (o) 83222； RD and G；O two RL gem groups together with their attached atoms form a residual cyclic acrylonitrile； RN1 is selected from the group consisting of hydrogen and tar c83218331832626；1.Hidroxi-Acquilo C832232833126；a.Halo-Acquilo C83223531832626；1.Amino-Acquilo C83225331832626；Ciano-Acquilo C83225331832626，Alcoxi C83218C83331°-832627-Acquilo C8321
