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Thiadiazole, like the same, and Methods for the treatment of conditions associated with SMN deficiency
专利权人:
NOVARTIS AG
发明人:
NATALIE DALES,JAKE AXFORD,MOO SUNG
申请号:
ARP140100200
公开号:
AR094557A1
申请日:
2014.01.23
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
Claim 1: A compound, or salt thereof, said compound is represented by the formula (1) wherein A is phenyl which is substituted by 0, 1, 2, or 3 substituents independently selected from C₁₋₄ alkyl,a. Two groups of c83216c83318324 can combine with atoms to form rings of 5-6 members, and can be replaced by 0 or 1 substitute selected from oxo, oxima, hydroxy, halo codilo c83216c83318324;Dihalide asphalt c8321c83318324;Trihalon asphalt c8321c83318324;C₁₋₄ alkoxy,C₁₋₄ alkoxy-Cal cycloalkyl,halo C₁₋₄ alkoxy,dihalo-C₁₋₄ alkoxy,trihalo-C₁₋₄ alkoxy,hydroxyl, cyano, halogen, amino, mono- and di-C₁₋₄-alkyl alkyl, heteroaryl, C₁₋₄ alkyl substituted by hydroxyl, C₁₋₄ alkoxy substituted by aryl, amino, -C (O) NH-C₁₋₄-alkyl heteroaryl, -NHC (O) -C₁₋₄-heteroaryl alkyl, C₁₋₄-C (O) alkyl NH-heteroaryl, C₁₋₄-NHC (O) -heteroaryl alkyl, 3-7 membered cycloalkyl, 5-cycloalkenyl - 7 members or 5, 6 or 9 member heterocycle containing 1 or 2 heteroatoms, independently selected from S, O and N, wherein heteroaryl has 5, 6 or 9 ring atoms, 1, 2 or 3 heteroatoms of ring selected from N, O and S and replaced by 0,1 or 2 substituents independently selected from oxo, hydroxyl, nitro, halogen, C₁₋₄ alkyl,C₁₋₄ alkenyl,C₁₋₄ alkoxy,C₃₋₇ cycloalkyl,C₁₋₄-OH alkyl, trihalo-C₁₋₄ alkyl,mono- y di-alquil C amino -C (O) NH-NH832222,-No.8322;hidroxi-alquil C amino hidroxi-alquilo Cheterocycle of 4-7 members-C₁₋₄ alkyl,amino-C₁₋₄ alkyl and mono- and di-C₁₋₄-alkyl-C₁₋₄ alkyl;or A is 6-membered heteroaryl having 1-3 ring nitrogen atoms, such 6-membered heteroaryl is substituted by phenyl or a heteroaryl having 5 or 6 ring atoms, 1 or 2 ring heteroatoms independently selected from N, O and S and substituted by 0, 1 or 2 substituents independently selected from C₁₋₄ alkyl,mono- y di-alquil C amino hidroxi-alquil C amino hidroxi-alquilo Camino-C₁₋₄ alkyl and mono- and di-C₁₋₄-alkyl-C₁₋₄ alkyl;O a is a single ring heteromorphic, which consists of 9 to 10 ring atoms and 1, 2 or 3 heteromorphic ring atoms selected inde
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