RANCATI, Fabio,RIZZI, Andrea,CARZANIGA, Laura,LINNEY, Ian,KNIGHT, Chris,SCHMIDT, Wolfgang
申请号：
PE2017001368
公开号：
PE20171347A1
申请日:
2016.02.10
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
A formula compound (I),Q is Y1 or Y2 as shown in the figure； A1 and A2 are not or are not (C1-C12) tar (c3-c8) CYCLOPROPYLENE, etc.； B is not or (c3-c8) CYCLOPROPYLENE (c3-c8) CYCLOPROPYLENE (c3-c8) CYCLOPROPYLENE (c3-c8), among others； C is not or is -,-C（o）……D is, inter Alia, deficient in tar (C1-C12) or tar (c2-c12) base； N and s are equal to 0, 1, 2 or 3； E is deficient in tar or - or- yes.Among other things, G is arileno or heterosexual and can be replaced optionally； R1 is (c3-c8) non cyclopentadiene (c3-c8) isocyclopentadiene (c3-c8), etc.； R2 is one containing n-nr3r4； R3 and R4 are h, or (C1-C4) tar, or R2 may be another group. It is a selected compound: 2-hydroxy-2 - (3 - ((5 - ((R) - 2-hydroxy-2 - (8-hydroxi-oxo-1, 2-dihydroquinlin-5-il) ethyl) amino (amyl) dioxyphenyl) - 2-phenylacetic acid (1-beniciperidin-4-il)； methyl, etc. He also mentioned a pharmacology composer, a composer and a device. This compound has an antagonistic effect on muscle receptor and an stimulative effect on adrenaline receptor.It is useful in the treatment of asthma, chronic obstructive pulmonary disease (EPOC) and other lung diseases,Among other thingsSe refiere a un compuesto de formula (I), donde Q es como se muestra en la figura, Y es Y1 o Y2； A1 y A2 estan ausentes o son (C1-C12)alquileno, (C3-C8)cicloalquileno, entre otros； B esta ausente o es (C3-C8)cicloalquileno； (C3-C8)heterocicloalquileno, entre otros； C esta ausente o es -O-, -C(O)-, entre otros； D esta ausente o es (C1-C12)alquileno, (C2-C12)alquenileno, entre otros； n y s son 0, 1, 2 o 3； E esta ausente o es -O-, -S-, entre otros； G es arileno o heteroarileno, opcionalmente sustituido； R1 es (C3-C8)cicloalquilo, (C3-C8)heterocicloalquilo, entre otros； R2 es un grupo que contiene N tal como -NR3R4； R3 y R4 son H o (C1-C4)alquilo, o R2 puede ser otro grupo. Es un compuesto seleccionado: 2-hidroxi-2-(3-((5-(((R)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etil)amino)pentil)oxi)fenil)-2-fenilacetato de (1-benci
