DIMARCHI RICHARD DENNIS,GLAESNER WOLFGANG,MILLICAN ROHN LEE JUNIOR,VICK ANDREW MARK,ZHANG LIANSHAN
申请号：
SI200431937
公开号：
SI1605897T1
申请日:
2004.03.19
申请国别(地区):
SI
年份:
2012
代理人:
摘要：
The invention provides GLP-1 compounds coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating diabetes, obesity, irritable bowel syndrome and other conditions that would be benefited by lowering plasma glucose, inhibiting gastric and/or intestinal motility and inhibiting gastric and/or intestinal emptying, or inhibiting food intake.
