Lianshan Zhang;Wolfgang Glaesner;John Philip Mayer;Rohn Lee Millican, Jr.;Andrew Mark Vick
发明人:
Wolfgang Glaesner,John Philip Mayer,Rohn Lee Millican, Jr.,Andrew Mark Vick,Lianshan Zhang
申请号：
US11913365
公开号：
US08183340B2
申请日:
2006.05.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides GLP-1 compounds coupled to two polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating conditions or disorders benefited by lowering blood glucose, decreasing food intake, decreasing gastric or intestinal emptying, increasing beta (β) cell population, or decreasing gastric or intestinal motility.
