PROBLEM TO BE SOLVED: To provide a production method of a tablet excellent in moldability and disintegration obtained by compressing granulated powder containing at least a hydrophobic drug excellent in flowability, compression moldability, and disintegration.SOLUTION: A production method of a tablet containing a hydrophobic drug comprises at least: a granulation step of granulating powder including a drug containing at least a hydrophobic drug while adding aqueous dispersion containing at least hydroxypropylcellulose having a low substitution degree whose substitution degree of a hydroxypropoxy group is 7 to 16 mass%, and saccharide or sugar alcohol, and obtaining a granulated material and a compression step of compressing the granulated material, and obtaining a tablet.COPYRIGHT: (C)2014,JPO&INPIT【課題】流動性、圧縮成形性、崩壊性に優れた疎水性薬物を少なくとも含む造粒末を提供し、それを打錠することにより成形性、崩壊性に優れる錠剤の製造方法を提供する。【解決手段】ヒドロキシプロポキシ基置換度が7~16質量%である低置換度ヒドロキシプロピルセルロースと、糖又は糖アルコールとを少なくとも含んでなる水分散液を添加しながら、疎水性薬物を少なくとも含む薬物含有粉体の造粒を行い、造粒物を得る造粒工程と、前記造粒物を打錠して錠剤を得る打錠工程とを少なくとも含んでなる疎水性薬物含有錠剤の製造方法を提供する。【選択図】なし
