PROBLEM TO BE SOLVED: To obtain tablets having a high hardness from a powdery functional substance having an inferior compression-molding property by using a small amount of a binder as much as possible.SOLUTION: This method for producing granules includes a process of attaching a micronized binder for granulation uniformly to the powdery functional substance having the inferior compression-molding property, and a process of performing the granulation by bringing particles of the functional substance attached with a binder for the granulation in contact with each other, and the both processes may be performed simultaneously and the binder for granulation is a water soluble cellulose derivative.COPYRIGHT: (C)2011,JPO&INPIT【課題】できるだけ少量の結合剤を用いて、圧縮成形性に劣る粉末状の機能性物質から高い硬度の錠剤を得ること。【解決手段】圧縮成形性に劣る粉末状の機能性物質に対し、微細化された造粒用結合剤を均一に付着させる工程;及び造粒用結合剤を付着させた機能性物質の粒子同士を接触させることにより造粒を行う工程;を包含し、両工程は同時に行われてもよい、顆粒の製造方法であって、該造粒用結合剤が水溶性セルロース誘導体である顆粒の製造方法。【選択図】なし
