ВАДРЕВУ Кришна Мохан (IN),ВЕЕРАБАДРАН Селви (IN),ПРАСАД Сай Девараджулу (IN)
申请号：
RU2012101464/10
公开号：
RU2012101464A
申请日:
2010.01.25
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A composition comprising: (a) a viral antigen, which is live attenuated rotavirus, and (b) a pharmaceutically acceptable buffer with physiological pH, while the stability of the composition against virus titer is increased, since the effect of the virus multiplying in the presence of serum albumin human stability is greater than the virus propagated in the absence of human serum albumin. 2. The composition according to claim 1, additionally containing at least one of the stabilizers, including a non-viral protein, or at least partially hydrolyzed hydrolyzate of such a protein, or individual disaccharides, or a combination of 2 disaccharides. The composition of claim 2, wherein the non-viral protein or protein hydrolyzate comprises at least one of the following: lactalbumin hydrolyzate, yeast hydrolyzate, gelatin hydrolyzate, egg protein hydrolyzate, peptone or vegetable protein selected from corn protein, wheat protein, chickpea protein , common bean protein, lentil protein, Lima bean protein, Turkish bean protein, soy protein, peeled pea protein or similar protein, an example of which is human serum albumin. 4. The composition of claim 3, wherein said protein hydrolyzate is a lactalbumin hydrolyzate. The composition of claim 2, wherein the disaccharide is trehalose. The composition of claim 2, wherein the combination of 2 disaccharides comprises sucrose and trehalose. The composition of claim 1, comprising (a) a viral antigen that is live attenuated rotavirus, (b) a pharmaceutically acceptable physiological pH buffer, and (c) a non-viral protein or protein hydrolyzate. K�1. Композиция, содержащая:(a) вирусный антиген, который является живым аттенуированным ротавирусом, и(b) фармацевтически приемлемый буфер с физиологическим значением pH,при этом стабильность композиции в отношении титра вирусов повышена, так как влияние вируса, размножающегося в присутствии сывороточного альбумина человека, на стабильность больше, чем вируса, размножаемого в отсутствие сывороточ
