#$%^&*AU2014100888A420140911.pdf#####ABSTRACT Protein purification techniques can be used successfully as virus clearance techniques as well as protein purification techniques. Particular methods show high efficiency when used in combination with other methods, or when performed in particular orders. By combining methods in particular ways, the inventors have established methods which can effectively purify proteins and clear proteins of viruses in a highly efficient manner. The methods of the present invention provide compositions in which proteins are totally or substantially cleared of viruses without unduly compromising protein yield. -33-