ЮСИБОВ Вайдеди (US),ФЭРРЕНС Кристина Е. (US),МАСЮЧУК Константин А. (US),МЕТТ Вадим (US),МЕТТ Валентина (US)
申请号：
RU2012114483/10
公开号：
RU2012114483A
申请日:
2010.09.16
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A virus-like particle containing a fusion protein in which this fusion protein contains a plant virus envelope protein and a target protein, and in which this plant virus envelope protein is derived from a plant virus envelope protein selected from the group consisting of alfalfa mosaic virus, virus mosaics of sorghum of Aleppo and Y-potato virus. 2. The virus-like particle of claim 1, wherein the target protein is derived from a cell surface polypeptide of an intracellular pathogen. The virus-like particle according to claim 1, wherein the target protein is derived from a cell surface polypeptide of a tropical malaria pathogen Plasmodium falciparum. The virus-like particle according to claim 1, wherein the target protein is derived from an influenza virus hemagglutinin polypeptide. The virus-like particle according to claim 4, wherein the influenza virus is influenza A virus selected from the group consisting of H1N1, H3N2, H5N1 and H7IM7.6. The virus-like particle according to claim 4, wherein the influenza virus is influenza virus B.7. The virus-like particle according to claim 1, wherein the target protein contains an amino acid sequence selected from the group consisting of SEQ ID NOs: 4-11 and 49, and antigenic fragments thereof. The virus-like particle according to claim 1, wherein the target protein is fused to the N-terminus of the plant virus coat protein. The virus-like particle according to claim 1, wherein the virus-like particle is created in a host cell selected from the group consisting of cells of bacteria, fungi, plants, insects, amphibians and mammals. An immunogenic composition containing a virus-like particle in which this virus-like particle contains a fusion protein, and this fusion protein contains a plant virus envelope protein and a target protein1. Вирусоподобная частица, содержащая белок слияния, в которой этот белок слияния содержит белок оболочки растительного вируса и белок-мишень, и в которой этот белок оболочки растительного вирус
