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Bicyclic compounds such as acetyl-CoA carboxylase (ACC) inhibitors
专利权人:
TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人:
YASUMA, TSUNEO,KAMATA, MAKOTO,YAMASHITA, TOHRU,HIROSE, HIDEKI,MURAKAMI, MASATAKA,KINA, ASATO,YONEMORI, KAZUKO,MIZOJIRI, RYO,FUJIMORI, IKUO,FUJIMOTO, TAKUYA,IKEDA, ZENICHI
申请号:
ES11802168
公开号:
ES2536319T3
申请日:
2011.11.29
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound represented by the formula (I): in which R1 is a group represented by the formula: -COR2 in which R2 is (a) a C1-6 alkyl group optionally substituted with 1 to 3 halogen atoms; (b) a C1-6 alkoxy group; or (c) an optionally mono or disubstituted amino group with a C1-6 alkyl group or groups; R3 is a C1-6 alkyl group optionally substituted with a halogen atom or atoms, or an optionally substituted C3-6 cycloalkyl group; R4a and R4b are independently a hydrogen atom or a substituent; X is O, CO, CR5aR5b, in which R5a and R5b are independently a hydrogen atom or a substituent, NR5c, in which R5c is a hydrogen atom or an optionally substituted C1-6 alkyl group, S, SO or S (O) 2; Ring A is an additionally optionally substituted 5 or 6 membered aromatic ring; for the P ring and the Q ring, (1) the P ring is an additionally optionally substituted 5-membered aromatic ring, the Q ring is an optionally substituted 6-membered ring, and the P ring and the Q ring are fused to forming an additionally optionally substituted bicyclic aromatic ring, or (2) the P ring is an additionally optionally substituted 5-membered non-aromatic ring, the Q ring is an additionally optionally substituted 6-membered aromatic ring, and the P ring and the Q ring fuse to form an additionally optionally substituted bicyclic non-aromatic ring; and R6 is an optionally substituted C1-6 alkyl group or an optionally substituted C3-6 cycloalkyl group, or a pharmacologically acceptable salt thereof.Un compuesto representado por la fórmula (I): en la que R1 es un grupo representado por la fórmula: -COR2 en la que R2 es (a) un grupo alquilo C1-6 opcionalmente sustituido con 1 a 3 átomos de halógeno; (b) un grupo alcoxi C1-6; o (c) un grupo amino opcionalmente mono o disustituido con un grupo o grupos alquilo C1-6; R3 es un grupo alquilo C1-6 opcionalmente sustituido con un átomo o átomos de halógeno, o un grupo cicloalquilo C3-6 opcionalmente sustituido; R4a y R4b son independientemente un átomo de hi
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