CHEN, LI,DILLON, MICHAEL PATRICK,FENG, LICHUN,HAWLEY, RONALD CHARLES,YANG, MINMIN
申请号：
ES08863325
公开号：
ES2417182T3
申请日:
2008.12.08
申请国别(地区):
ES
年份:
2013
代理人:
摘要：
Compound of formula I: or pharmaceutically acceptable salts thereof, wherein: R1 is pyrazolyl optionally substituted, R2 is optionally substituted phenyl, substituted pyridinyl optionally substituted pyrimidinyl optionally pyridazinyl optionally substituted or thiophenyl optionally substituted, R3 is hydrogen, alkyl- C1-6, C1-6 heteroalkyl-or cyano, R4 is hydrogen, C1-6-alkyl or C1-6 heteroalkyl-or R3 and R4 together with the atom to which they are attached may form a C3-6 carbocyclic ring, R5 is 1-6C alkyl, C1-6 heteroalkyl-, C1-6-haloalkyl, C1-6-N-alkylamino, N, N-dialkylamino-C1-6 cycloalkyl-C37, aryl, heteroaryl, heterocyclyl, cycloalkyl C3-7-C1-6-alkyl, heteroaryl-C1-6, C1-6-heterocyclyl, aryl-C1-6alkyl, aryloxy-C1-6-alkyl, (CR3Rb) mC (O) -R8 , wherein m is 0 or 1, Ra and Rb are each independently hydrogen or 1-6C alkyl, and R8 is hydrogen, C1-6-alkyl, C1-6-heteroalkyl, cycloalkyl C3-7, aryl, heteroaryl, heterocyclyl, cycloalkyl-C3-7-C1-6, C1-6-arylalkyl, hetero-C 1-6 alkyl, heterocyclyl-C1-6 cycloalkyloxy-C3-7, aryloxy, heteroaryloxy, heterocyclyloxy, cycloalkyloxy-C3-7-C1-6alkyl, aryloxy-C1-6alkyl, heteroaryloxy-C1-6alkyl, C1-6alkyl or -NR9R10 heterocyclyloxy-, in which: R9 is hydrogen or C1- -6, and R10 is hydrogen, C1-6-alkyl-C1-6 alkyl-C3-7-cycloalkyl, hetero-C1-6 alkyl, C3-7 cycloalkyl-alkyl, aryl, heteroaryl, heterocyclyl, arylalkyl-C1- 6, heteroaryl-C1-6 alkyl or heterocyclyl-C1-6 alkyl, or R4 and R5 together with the atom to which they are attached may form a C3-6 carbocyclic ring, which is optionally substituted with hydroxy, or R4 and R5 together with the atom to which they are attached may form a heterocyclic-C4-6 ring containing one or two heteroatoms, selected each independently from O, N and S, or R3, R4 and R5 together with the atom to which Meeting on an attached form a six-membered heteroaryl containing one or two nitrogen atoms, which is optionally substituted with halo, amino or 1-6C alkyl, and R6, R7 and R8 each independently is hydrogen, a
