TULLY, David,CHIANELLI, Donatella,LIU, Xiaodong,MOLTENI, Valentina,NELSON, John,ROLAND, Jason,RUCKER, Paul
申请号：
ES14803001
公开号：
ES2670984T3
申请日:
2014.11.04
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound according to formula (I), ** Formula ** or a pharmaceutically acceptable salt thereof, wherein, R0 is Ring A or C1-6 alkyl； Ring A is aryl； 5-10 membered heteroaryl comprising 1-3 N, O or S heteroatoms； or C3-7 cycloalkyl； and said Ring A is unsubstituted or substituted with 1-2 substituents independently represented by R2； Ring B is aryl； 5-10 membered heteroaryl comprising 1-3 N, O or S heteroatoms； or C3-7 cycloalkyl； and said Ring B is unsubstituted or substituted with 1-2 substituents independently represented by R2； X is - (CR4R5) -； Y is -O-, - (CR4R5) -, or * -O (CR4R5) -, in which "*" indicates the point of attachment of Y to the ring containing the ring atoms Z； Z1, Z2, Z3, and Z4 are each independently -CR3- or -N-； L1 is * 1- (CR4R5) 1-2- in which "* 1" indicates the junction point of L1 to N； L2 is * 2- (CR4R5) 1-2-, * 2- (CR4R5) -C (O) -NR-, * 2- (CR4R5) 2-O-, * 2- (CR4R5) 2-NR- or * 2- (CR4R5) -C (O) -NR- (CR4R5) -； in which "* 2" indicates the point of attachment of L2 to N； L3 is -C (O) -； each R2 is independently halo, C1-6 alkyl, or halo-C1-6 substituted alkyl； each R3 is independently hydrogen, halo, or C1-6 alkyl； R, R4 and R5 are independently hydrogen or C1-6 alkyl.Un compuesto de acuerdo con la fórmula (I),**Fórmula** o una sal farmacéuticamente aceptable del mismo, en la que, R0 es el Anillo A o alquilo C1-6； el Anillo A es arilo； heteroarilo de 5-10 miembros que comprende 1-3 heteroátomos N, O o S； o cicloalquilo C3-7； y dicho Anillo A está sin sustituir o sustituido con 1-2 sustituyentes representados independientemente por R2； el Anillo B es arilo； heteroarilo de 5-10 miembros que comprende 1-3 heteroátomos N, O o S； o cicloalquilo C3-7； y dicho Anillo B está sin sustituir o sustituido con 1-2 sustituyentes representados independientemente por R2； X es -(CR4R5)-； Y es -O-, -(CR4R5)-, o *-O(CR4R5)-, en la que "*" indica el punto de unión de Y al anillo que contiene los átomos de anillo Z； Z1, Z2, Z3, y Z4 son cada uno independie
