COATE, HEATHER R.,DVORAK, CURT A.,FITZGERALD, ANNE E.,LEBOLD, TERRY P.,PREVILLE, CATHY,SHIREMAN, BROCK T.
申请号：
PE0019412015
公开号：
PE16682015A1
申请日:
2014.03.12
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
The present Invention relates to compounds of formula I, where the phenyl ring is, naftalenilo, piridilo, quinolinilo, isoquinolinilo, imidazopiridilo, furanilo, thiazolyl, isoxazolilo, pirazolilo, imidazotiazolilo, bencimidazolilo, or indazolilo r1 is H, alkyl, alkoxy hidroxialquileno, Oh, Halo, phenyl, triazolilo, oxazolilo, isoxazolilo, piridilo, pirimidinilo, pirazinilo,Piridazinilo, piperazinilo, pirazolilo, oxadiazolilo, pirrolidinilo, tiofenilo, morfolinilo, or dialquilamino R2 is H, alkyl, alkoxy hidroxialquileno or Halo Z is NH, N - alkyl, or is piridilo R5, pirimidinilo, pirazinilo, piridazinilo, quinazolinilo, quinoxalinilo, pirazolilo, benzoxazolilo, Imidazopirazinilo, triazolopirazinilo,Optionally substituted with one or two substituents independently selected from the group consisting of alkyl, alkoxy, or Halo and N is 0 OR 1. In addition, we describe methods for preparing compounds of formula I. The Invention relates also to pharmaceutical compositions comprising compounds of formula I.Methods of use of the compounds of the invention are also within the scope of the inventionLa presente invencion se refiere a compuestos de Formula l, en donde el anillo A es fenilo, naftalenilo, piridilo, quinolinilo, isoquinolinilo, imidazopiridilo, furanilo, tiazolilo, isoxazolilo, pirazolilo, imidazotiazolilo, bencimidazolilo, o indazolilo R1 es H, alquilo, alcoxi hidroxialquileno, OH, halo, fenilo, triazolilo, oxazolilo, isoxazolilo, piridilo, pirimidinilo, pirazinilo, piridazinilo, piperazinilo, pirazolilo, oxadiazolilo, pirrolidinilo, tiofenilo, morfolinilo, o dialquilamino R2 es H, alquilo, alcoxi hidroxialquileno, o halo Z es NH, N-alquilo, u O R5 es piridilo, pirimidinilo, pirazinilo, piridazinilo, quinazolinilo, quinoxalinilo, pirazolilo, benzoxazolilo, imidazopirazinilo, triazolopirazinilo, opcionalmente sustituido con uno o dos sustituyentes independientemente seleccionados del grupo que consiste en alquilo, alcoxi, o halo y n es 0 o 1 . Ademas, se describe
