Described herein are particles comprising a first compartment, a second compartment, and a compound of Formula (I), as well as compositions and methods of making and using the same. The particles may comprise a cell capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.本文描述的是包含第一室、第二室和具有式(I)之化合物的顆粒,以及製備和使用其之組成物及方法。該等顆粒可包含能夠表現有用於治療本文所述疾病、障礙或病症的治療劑的細胞。