A complex comprising a GDF15 polypeptide is described. Methods of treating individuals with a metabolism disorder, such as, glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.本發明描述一種包含GDF15多肽之複合物。提供治療具有諸如葡萄糖代謝病症之代謝病症及/或體重病症之個體的方法及與此相關之組合物。