The present invention discloses a method for producing a composition comprising archaeal lipids from a Sulfolobus cell culture, comprising(1) growing a Sulfolobus cell culture at a temperature of 75 to 85°C and at a growth rate of 0.025 to 0.035 per hour and extracting the archaeal lipids from the archaeal culture so as to obtain a composition for use for oral retard therapy, or(2) growing a Sulfolobus cell culture at a temperature of 75 to 85°C and at a growth rate of 0.005 to 0.015 per hour and extracting the archaeal lipids from the archaeal culture so as to obtain a composition for use for oral acute therapy;and compositions obtainable by such method.