ANDRES-GIL, JOSE IGNACIO,ALCAZAR-VACA, MANUEL JESUS,DAUTZENBERG, FRANK MATTHIAS,LINDERS, JOANNES THEODORUS MARIA
申请号：
CA2664112
公开号：
CA2664112C
申请日:
2007.12.04
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention concerns aryl and heteroaryl substituted diaza-spiro-pyridinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I), a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders； obesity； diabetes； sexual disorders and neurological disorders.
