Novel substituted diaza-spiro-pyridinone derivatives for use in diseases mediated by MCH-1

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专利权人:

ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ

发明人:

アンドレ－ジル，ホセ・イグナシオ,アルカザル－バカ，マヌエル・イエズス,ドーツエンベルク，フランク・マテイアス,リンダース，ヨアネス・テオドルス・マリア,アンドレ-ジル,ホセ・イグナシオ,アルカザル-バカ,マヌエル・イエズス,ドーツエンベルク,フランク・マテイアス,リンダース,ヨアネス・テオドルス・マリア

申请号：

JP2009539736

公开号：

JP5290192B2

申请日:

2007.12.04

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The present invention concerns aryl and heteroaryl substituted diaza-spiro-pyridinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders； obesity； diabetes； sexual disorders and neurological disorders.

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