Manuel Jesús Alcázar-Vaca;Joannes Theodorus Maria Linders;Frank Matthias Dautzenberg;José Ignacio Andrés-Gil
发明人:
José Ignacio Andrés-Gil,Manuel Jesús Alcázar-Vaca,Frank Matthias Dautzenberg,Joannes Theodorus Maria Linders
申请号:
US12444878
公开号:
US08158643B2
申请日:
2007.12.04
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention concerns aryl and heteroaryl substituted diaza-spiro-pyridinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I)a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.