Manuel Jesús Alcázar-Vaca;Rosa María Álvarez-Escobar;Frank Matthias Dautzenberg;Jacqueline Macritchie;Sonia Martinez Gonzalez;Donald Simpson;Julen Oyarzabal Santamarina;José Ignacio Andrés-Gil
发明人:
José Ignacio Andrés-Gil,Manuel Jesús Alcázar-Vaca,Rosa María Álvarez-Escobar,Julen Oyarzabal Santamarina,Frank Matthias Dautzenberg,Jacqueline Macritchie,Donald Simpson,Sonia Martinez Gonzalez
申请号：
US12091365
公开号：
US08329704B2
申请日:
2006.12.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention concerns aryl and heteroaryl substituted pyrazinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I)a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders； obesity； diabetes； sexual disorders and neurological disorders.
