The present invention relates to pyrazolo-quinazolines, characterized by an ortho-substituted-arylamino, heterocyclylamino- or C3-C7cycloalkylamino residue at 8 position and an aryl, heterocyclyl or C3-C7cycloalkyl as substituent of a carboxamide at 3 position of the molecula framework.The compounds of this invention modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular MPS1/TTK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.本發明係關於吡唑并-喹唑啉化合物，其特徵在於位於分子骨架8位置之經鄰位取代之芳基胺基、雜環基胺基或C3-C7環烷基胺基殘基及芳基、雜環基或C3-C7環烷基作為於分子骨架3位置之羧醯胺之取代基。本發明化合物調控蛋白質激酶活性，因此可用於治療由蛋白質激酶活性特別為MPS1/TTK失調所引發的疾病。本發明也提供用於製備此等化合物之方法、包含此等化合物之醫藥組成物，及利用包含此等化合物之醫藥組成物治療疾病之方法。
