The invention concerns therapeutic uses of compounds of general formula (I), wherein n, X1, X2, X3, X4, Z1, Z2, Z3, Z4, Z5 and W are as defined herein. Said compounds are ligands of the TRPV1 vanilloid receptor, and are therefore, useful for treating diseases associated with TRPV1 receptors, such as pain and inflammation among others as disclosed and specifically claimed.本發明係關於通式(I)之化合物：其中，n等於0、1、2或3；X1、X2、X3、X4、Z1、Z2、Z3、Z4及Z5各自獨立表示氫原子或鹵素原子或C1－C6－烷基、C3－C7－環烷基、C3－C7－環烷基－C1－C3－伸烷基、C1－C6－氟烷基、C1－C6－烷氧基、C1－C6－氟烷氧基、氰基、C(O)NR1R2、硝基、NR1R2、C1－C6－硫烷基、－S(O)－C1－C6－烷基、－S(O)2－C1－C6－烷基、SO2NR1R2、NR3COR4、NR3SO2R5或芳基，該芳基係視情況經取代；W表示下式之稠合雙環基團：其經由1、2、3或4位置連接至氮原子；A表示視情況經取代之5－員或7－員雜環，其包含自一至三個選自O、S及N之雜原子；該化合物以鹼或酸－加成鹽形式存在，且亦可以水合物或溶劑合物形式存在。；本發明亦關於其製備方法及治療應用。
