Procedure preparation of the Metabolites of (4) and (4R) - 4 - (cyano - 2-methoxyphenyl) - 5 - ethoxy - 2.8 - dimethyl - 1,4 - dihydro - 1.6 - naftiridina - 3 - carboxamide and Use thereof

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专利权人:

BAYER PHARMA AKTIENGESELLSCHAFT

发明人:

PLATZEK, Johannes,ZORN, Ludwig

申请号：

CL2018000428

公开号：

CL2018000428A1

申请日:

2018.02.16

申请国别(地区):

CL

年份:

2018

代理人:

摘要：

The present invention relates to a novel method for preparing (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula 4R (I) and the metabolites of (4S)- and (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I), the formulae M1a (S), M1b (R), M2a (S), M2b (R), M3a (S) and M3b (R) and use thereof.PROCEDIMIENTO DE PREPARACIÓN DE LOS METABOLITOS DE (4S) Y (4R)-4-(4-CIANO-2-METOXIFENIL)-5-ETOXI-2,8-DIMETIL-1,4-DIHIDRO-1,6-NAFTIRIDINA-3-CARBOXAMIDA Y USO DE LOS MISMOS

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