Method for preparing (4s) and (4r) -4- (4-cyano-2-methoxyphenyl) -5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-metabolites 3-carboxamide and their use
The present invention relates to an innovative method for preparing (4r) -4- (4-cyano-2-methoxyphenyl) -5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine 3-carboxamide of formula 4r (i) and the metabolites of (4s) and (4r) -4- (4-cyano-2-methoxyphenyl) -5-ethoxy-2,8-dimethyl-1,4-di- hydro-1,6-naphthyridine-3-carboxamide of formula (i), formulas m1a (s), m1b (r), m2a (s), m2b (r), m3a (s) and m3b (r), and use of them.a presente invenção se refere a um método inovador para preparar (4r)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-di-hidro-1,6-naftiridina-3-carboxamida da fórmula 4r (i) e os metabólitos de (4s) e (4r)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-di-hidro-1,6-naftiridina-3-carboxamida da fórmula (i), das fórmulas m1a (s), m1b (r), m2a (s), m2b (r), m3a (s) e m3b (r), e uso dos mesmos.
