Procedure for the preparation of (4S) - 4 - (cyano - 2-methoxyphenyl) - 5 - toxi - 2.8 - dimethyl - 1,4 - dihydro - - - - - 3 naftiridin Carbox amide and its purification for use as pharmaceutical Active principle
DR. JOHANNES PLATZEK,DR. GUNNAR GARKE,DR. ALFONS GRUNENBERG
申请号：
UY36251
公开号：
UY36251A
申请日:
2015.07.31
申请国别(地区):
UY
年份:
2016
代理人:
摘要：
The present Invention refers to a new and improved process for the preparation of (4S) - 4 - (4 - cyano - 2-methoxyphenyl) - 5 - ethoxy - 2.8 - dimethyl - 1,4 - dihydro - - - - - 3 naftiridin Carbox amide of the formula (i) as well as the preparation and I use the Crystalline Modification of (4S) - 4 - (C Y - 2-methoxyphenyl) - 5 - ethoxy - 2.8 - dimethyl - 1,4 - dihydro - - - - - 3 naftiridin Carbox amide of the formula (i).La presente invención se refiere a un procedimiento nuevo y mejorado para la preparación de (4S)-5 4-(4-Ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carbox-amida de la fórmula (I) así como la preparación y utilización de la modificación cristalina I de (4S)- 4-(4-Ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carbox-amida de la fórmula (I)..
